An emerging body of evidence has been involved in plasminogen activator inhibitor-1 (PAI-1) in the development of type 2 diabetes (T2D), though the findings are not always consistent. Our systematic epidemiological studies examining the association of PAI-1 with T2D.
EMBASE, PubMed, Web of Science, and the Cochrane Library were searched to identify studies for inclusion. Fifty-two studies (44 cross-sectional with 47 unique analytical comparisons and 8 candidates) included. In a random-effects pooled analysis of prospective studies, a comparison of the three vs three under basic PAI-1 values generated T2D RR of 1.67 (95% CI 1.28 to 2.18) with moderate heterogeneity (I (2) = 38 %).
In addition, of 47 comparative cross-sectional study, 34 (72%) reported a significant increase in PAI-1 in the case of diabetes compared with controls, 2 (4%) reported significantly increased PAI-1 in the control, and 11 (24%) reported null effect. Results from a pooled analysis of prospective studies did not differ substantially with the study design, the length of follow-up, adjustment for various confounding factors suspected of, or the quality of learning, and robust to sensitivity analysis.
The findings of this systematic review available epidemiological literature supports the relationship between PAI-1 and T2D, established independent risk factor for diabetes. Given the association of moderate size and heterogeneity across studies, prospective studies in the future guaranteed. Women with type 2 diabetes mellitus (T2DM) have a higher risk of fracture despite an increase in bone mineral density (BMD). In the experimental study the potential role of plasminogen activator inhibitor-1 (PAI-1) in bone remodeling advised but studies in humans are lacking.
Plasminogenactivatorinhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies.
Plasminogen driving inhibitors -1 concentration and bone mineral density in postmenopausal women with type of two diabetes mellitus.
BACKGROUND Women with type 2 diabetes mellitus (T2DM) have a higher risk of fracture despite an increase in bone mineral density (BMD). In the experimental study the potential role of plasminogen activator inhibitor-1 (PAI-1) in bone remodeling advised but studies in humans are lacking. This is the first study in humans to investigate whether circulating levels of PAI-1 in postmenopausal women with type 2 diabetes associated with BMD and adiposity.
METHOD Anthropometric variables, PAI-1 and insulin, serum lipids and markers of bone turnover were measured in 127 postmenopausal women with type 2 diabetes. A total of 117 female patients were divided according to lumbar spine BMD by dual-energy x-ray absorptiometry measurements in three groups: 47 with osteopenia, 21 with osteoporosis and 49 with normal BMD.4
RESULTS diabetic patients with normal BMD had significantly higher BMI, larger waist circumference and lower bone turnover markers of diabetic patients with osteopenia and osteoporosis. PAI-1 was lower in diabetic patients with osteoporosis and osteopenia compared to diabetics with normal BMD. Multiple regression analysis revealed insulin, triglyceride levels, pyrilinks and beta-blocker therapy to be the strongest predictors of PAI-1 levels. PAI-1 levels correlated with both L-BMD and hip BMD, but after adjustment for age and BMI association was no longer significant.
CONCLUSION Our findings suggest that elevated levels of PAI-1 associated with higher BMD in obese diabetic patients but the possible implications of these findings and the underlying mechanisms remain unclear. Obviously, the metabolic parameters, can affect both BMD and PAI-level, and the association of PAI-1 and metabolism are also reasonable.
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Plasminogen Activator Inhibitor 2 (PAI2) Protein
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen activator inhibitor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen activator inhibitor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen activator inhibitor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: Quantitativesandwich ELISA kit for measuring Mouse Plasminogen activator inhibitor 2 (SERPINB2) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativesandwich ELISA kit for measuring Mouse Plasminogen activator inhibitor 2(SERPINB2) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in plasma.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in plasma.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in plasma.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in plasma.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Plasminogen Activator Inhibitor 2 (PAI2) in samples from plasma with no significant corss-reactivity with analogues from other species.
Description: A competitive ELISA for quantitative measurement of Human Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA kit for quantitative measurement of Mouse PAI2 (Plasminogen Activator Inhibitor 2) in samples from Serum, Plasma, Cell supernatant
ELISA kit for Mouse PAI2 (Plasminogen Activator Inhibitor 2)
Description: A sandwich ELISA kit for detection of Plasminogen Activator Inhibitor 2 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
ELISA kit for Mouse Plasminogen activator inhibitor 2 (SERPINB2)
Description: A sandwich CLIA kit for quantitative measurement of Mouse PAI-2 (Plasminogen Activator Inhibitor 2) in samples from Serum, Plasma, Cell supernatant
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Plasminogen Activator Inhibitor 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor,PAI in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor,PAI in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse plasminogen activator inhibitor,PAI in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: Quantitativesandwich ELISA kit for measuring Human Plasminogen activator inhibitor 2 (SERPINB2) in samples from serum, plasma, cell culture supernates, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Human Plasminogen activator inhibitor 2(SERPINB2) ELISA kit
Description: Quantitativesandwich ELISA kit for measuring Human Plasminogen activator inhibitor 2(SERPINB2) in samples from serum, plasma, cell culture supernates, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Rat Plasminogen activator inhibitor 2 type A (Serpinb2)
Description: A competitive ELISA for quantitative measurement of Guinea pig Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Guinea pig Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Guinea pig Plasminogen Activator Inhibitor 2 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Rat Plasminogen activator inhibitor 2 type A (Serpinb2)
Description: A sandwich quantitative ELISA assay kit for detection of Human Plasminogen Activator Inhibitor 2 (PAI2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Human Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human Plasminogen Activator Inhibitor 2 (PAI2) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat Plasminogen Activator Inhibitor 2 (PAI2) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Plasminogen Activator Inhibitor 2 (PAI2) in plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
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Further research is needed to explain the nature of this modulator matrix interactions in relation to energy and bone metabolism in humans.
