Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies.
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August 7, 2020

Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies.

By Alyssa

An emerging body of evidence has been involved in plasminogen activator inhibitor-1 (PAI-1) in the development of type 2 diabetes (T2D), though the findings are not always consistent. Our systematic epidemiological studies examining the association of PAI-1 with T2D.

EMBASE, PubMed, Web of Science, and the Cochrane Library were searched to identify studies for inclusion. Fifty-two studies (44 cross-sectional with 47 unique analytical comparisons and 8 candidates) included. In a random-effects pooled analysis of prospective studies, a comparison of the three vs three under basic PAI-1 values ​​generated T2D RR of 1.67 (95% CI 1.28 to 2.18) with moderate heterogeneity (I (2) = 38 %).

In addition, of 47 comparative cross-sectional study, 34 (72%) reported a significant increase in PAI-1 in the case of diabetes compared with controls, 2 (4%) reported significantly increased PAI-1 in the control, and 11 (24%) reported null effect. Results from a pooled analysis of prospective studies did not differ substantially with the study design, the length of follow-up, adjustment for various confounding factors suspected of, or the quality of learning, and robust to sensitivity analysis.

The findings of this systematic review available epidemiological literature supports the relationship between PAI-1 and T2D, established independent risk factor for diabetes. Given the association of moderate size and heterogeneity across studies, prospective studies in the future guaranteed.
Women with type 2 diabetes mellitus (T2DM) have a higher risk of fracture despite an increase in bone mineral density (BMD). In the experimental study the potential role of plasminogen activator inhibitor-1 (PAI-1) in bone remodeling advised but studies in humans are lacking.

<em>Plasminogen</em> <em>activator</em> <em>inhibitor</em>-1 and type <em>2</em> diabetes: a systematic review and meta-analysis of observational studies.
Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies.

Plasminogen driving inhibitors -1 concentration and bone mineral density in postmenopausal women with type of two diabetes mellitus.

BACKGROUND
Women with type 2 diabetes mellitus (T2DM) have a higher risk of fracture despite an increase in bone mineral density (BMD). In the experimental study the potential role of plasminogen activator inhibitor-1 (PAI-1) in bone remodeling advised but studies in humans are lacking. This is the first study in humans to investigate whether circulating levels of PAI-1 in postmenopausal women with type 2 diabetes associated with BMD and adiposity.


METHOD
Anthropometric variables, PAI-1 and insulin, serum lipids and markers of bone turnover were measured in 127 postmenopausal women with type 2 diabetes. A total of 117 female patients were divided according to lumbar spine BMD by dual-energy x-ray absorptiometry measurements in three groups: 47 with osteopenia, 21 with osteoporosis and 49 with normal BMD.4


RESULTS
diabetic patients with normal BMD had significantly higher BMI, larger waist circumference and lower bone turnover markers of diabetic patients with osteopenia and osteoporosis. PAI-1 was lower in diabetic patients with osteoporosis and osteopenia compared to diabetics with normal BMD. Multiple regression analysis revealed insulin, triglyceride levels, pyrilinks and beta-blocker therapy to be the strongest predictors of PAI-1 levels. PAI-1 levels correlated with both L-BMD and hip BMD, but after adjustment for age and BMI association was no longer significant.


CONCLUSION
Our findings suggest that elevated levels of PAI-1 associated with higher BMD in obese diabetic patients but the possible implications of these findings and the underlying mechanisms remain unclear. Obviously, the metabolic parameters, can affect both BMD and PAI-level, and the association of PAI-1 and metabolism are also reasonable.

Recombinant Mouse Plasminogen activator inhibitor 1
MBS963855-002mgYeast 0.02mg(Yeast)
EUR 320

Recombinant Mouse Plasminogen activator inhibitor 1
MBS963855-01mgEColi 0.1mg(E-Coli)
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Recombinant Mouse Plasminogen activator inhibitor 1
MBS963855-01mgYeast 0.1mg(Yeast)
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Recombinant Mouse Plasminogen activator inhibitor 1
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EUR 1260

Recombinant mouse Plasminogen activator inhibitor 1
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EUR 380

Recombinant mouse Plasminogen activator inhibitor 1
MBS9420661-01mg 0.1mg
EUR 650

Recombinant mouse Plasminogen activator inhibitor 1
MBS9420661-1mg 1mg
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Recombinant mouse Plasminogen activator inhibitor 1
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Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)
CSB-EP021081MO 2166 mg Ask for price

Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)
CSB-EP021081MO-20ug 20ug Ask for price
Description: 23-402aa

Recombinant Mouse Plasminogen activator inhibitor 1(Serpine1)
AP70764 1mg
EUR 2826

Recombinant Mouse Plasminogen activator inhibitor 1(Serpine1)
AP72777 each Ask for price

Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)
CSB-YP021081MO 5989 mg Ask for price

Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)
CSB-YP021081MO-20ug 20ug Ask for price
Description: 23-402aa

Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)
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EUR 705.1

Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)
RPC21989-1mg 1mg
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RPC21989-20ug 20ug
EUR 353.4

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RPC24943-100ug 100ug
EUR 702.9

Recombinant Mouse Plasminogen activator inhibitor 1 (Serpine1)
RPC24943-20ug 20ug
EUR 353.4

Recombinant Mouse Plasminogen activator inhibitor 2, macrophage (Serpinb2)
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EUR 1285

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MBS962179-002mgEColi 0.02mg(E-Coli)
EUR 965

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MBS962179-002mgYeast 0.02mg(Yeast)
EUR 1080

Recombinant Mouse Plasminogen activator inhibitor 2, macrophage (Serpinb2)
MBS962179-01mgEColi 0.1mg(E-Coli)
EUR 1125

Recombinant Mouse Plasminogen activator inhibitor 2, macrophage (Serpinb2)
MBS962179-01mgYeast 0.1mg(Yeast)
EUR 1230

Recombinant Human Plasminogen Activator Inhibitor-2
AP60417 100ug
EUR 1554

Recombinant Human Plasminogen Activator Inhibitor-2
P1567-.01 10ug
EUR 272.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Plasminogen Activator Inhibitor-2
P1567-.1 100ug
EUR 1560.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Plasminogen Activator Inhibitor-2
P1567-.5 500ug
EUR 3503.2
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
MBS2018222-001mg 0.01mg
EUR 170

Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
MBS2018222-005mg 0.05mg
EUR 295

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MBS2018222-01mg 0.1mg
EUR 450

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EUR 1040

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MBS2018365-001mg 0.01mg
EUR 180

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MBS2018365-005mg 0.05mg
EUR 330

Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
MBS2018365-01mg 0.1mg
EUR 500

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MBS2018365-02mg 0.2mg
EUR 615

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MBS2018365-05mg 0.5mg
EUR 1170

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MBS2018456-001mg 0.01mg
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MBS2018456-005mg 0.05mg
EUR 315

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MBS2018456-01mg 0.1mg
EUR 475

Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
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EUR 580

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MBS2018456-05mg 0.5mg
EUR 1100

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4-RPA531Hu01
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  • 10ug
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Description: Recombinant Human Plasminogen Activator Inhibitor 2 expressed in: E.coli

Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
RPA531Mu01 10ug
EUR 182

Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
4-RPA531Mu01
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  • 10ug
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Description: Recombinant Mouse Plasminogen Activator Inhibitor 2 expressed in: E.coli

Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
RPA531Ra01 10ug
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Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
4-RPA531Ra01
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Description: Recombinant Rat Plasminogen Activator Inhibitor 2 expressed in: E.coli

Recombinant Plasminogen Activator Inhibitor 2 (PAI2)
RPU56751-100ug 100ug
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Recombinant human Plasminogen activator inhibitor 2
P1738 100ug Ask for price
Description: Recombinant protein for human Plasminogen activator inhibitor 2

Plasminogen Activator Inhibitor-1 (Recombinant)
20-abx073514
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Plasminogen Activator Inhibitor Type 1, Recombinant, Mouse (PAI-1)
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Description: Recombinant Human Plasminogen Activator Inhibitor 1 expressed in: E.coli

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
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EUR 152

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
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  • 10ug
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  • 1 mg
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Description: Recombinant Human Plasminogen Activator Inhibitor 1 expressed in: E.coli

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPA532Mu01 10ug
EUR 160

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
4-RPA532Mu01
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  • 10ug
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  • 1 mg
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Description: Recombinant Mouse Plasminogen Activator Inhibitor 1 expressed in: E.coli

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPA532Ra01 10ug
EUR 176

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
4-RPA532Ra01
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  • 10ug
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Description: Recombinant Rat Plasminogen Activator Inhibitor 1 expressed in: E.coli

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPA532Si01 10ug
EUR 164

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
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EUR 492.8

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
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EUR 2184

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RPU51492-50ug 50ug
EUR 396

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EUR 542.3

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
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EUR 2402.4

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU52990-50ug 50ug
EUR 435.6

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU55545-100ug 100ug
EUR 601.7

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU55545-1mg 1mg
EUR 2371.2

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU55545-50ug 50ug
EUR 364.8

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU56752-100ug 100ug
EUR 470.4

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU56752-1mg 1mg
EUR 2184

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU56752-50ug 50ug
EUR 385

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU43312-100ug 100ug
EUR 468.6

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU43312-1mg 1mg
EUR 2074.8

Recombinant Plasminogen Activator Inhibitor 1 (PAI1)
RPU43312-50ug 50ug
EUR 376.2

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
CSB-YP021070HU 5987 mg Ask for price

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
CSB-YP021070HU-20ug 20ug Ask for price
Description: 1-415aa

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
CSB-MP021070HU 4968 mg Ask for price

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
CSB-MP021070HU-20ug 20ug Ask for price
Description: 1-415aa

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
MBS965342-002mgMammalianCell 0.02mg(Mammalian-Cell)
EUR 425

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
MBS965342-002mgYeast 0.02mg(Yeast)
EUR 320

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
MBS965342-01mgMammalianCell 0.1mg(Mammalian-Cell)
EUR 1015

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
MBS965342-01mgYeast 0.1mg(Yeast)
EUR 515

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
MBS965342-05mgYeast 0.5mg(Yeast)
EUR 1260

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
RPC26411-100ug 100ug
EUR 1218.8

Recombinant Human Plasminogen activator inhibitor 2 (SERPINB2)
RPC26411-20ug 20ug
EUR 484

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS951741-002mgEColi 0.02mg(E-Coli)
EUR 320

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS951741-002mgYeast 0.02mg(Yeast)
EUR 320

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS951741-01mgEColi 0.1mg(E-Coli)
EUR 520

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS951741-01mgYeast 0.1mg(Yeast)
EUR 515

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS951741-05mgYeast 0.5mg(Yeast)
EUR 1260

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS9420660-002mg 0.02mg
EUR 380

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS9420660-01mg 0.1mg
EUR 650

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS9420660-1mg 1mg
EUR 2525

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS9420660-5x1mg 5x1mg
EUR 11205

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS9422489-002mg 0.02mg
EUR 380

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS9422489-01mg 0.1mg
EUR 650

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS9422489-05mg 0.5mg
EUR 1655

Recombinant Rat Plasminogen activator inhibitor 2 type A
MBS9422489-5x05mg 5x0.5mg
EUR 7290

Recombinant Human Plasminogen activator inhibitor 1
MBS1265498-002mgEColi 0.02mg(E-Coli)
EUR 255

Recombinant Human Plasminogen activator inhibitor 1
MBS1265498-01mgEColi 0.1mg(E-Coli)
EUR 405

Recombinant Human Plasminogen activator inhibitor 1
MBS1265498-1mgEColi 1mg(E-Coli)
EUR 1425

Recombinant Human Plasminogen activator inhibitor 1
MBS1265498-5x1mgEColi 5x1mg(E-Coli)
EUR 6215

Recombinant human Plasminogen activator inhibitor 1
MBS961954-005mg 0.05mg
EUR 260

Recombinant human Plasminogen activator inhibitor 1
MBS961954-02mg 0.2mg
EUR 560

Further research is needed to explain the nature of this modulator matrix interactions in relation to energy and bone metabolism in humans.

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