Author: Alyssa

August 8, 2021

Lampire Covid-19 Antibodies

LAMPIRE has added COVID-19 recombinant proteins and RNA lysis buffer to its product portfolio. These components of SARS CoV-2 include full-length trimeric peak, S1 glycoproteins, nucleocapsid, receptor-binding domain, and ACE2 proteins. These proteins are NOW AVAILABLE for research use only. Count on LAMPIRE as your critical research partner in the fight against COVID-19. Learn about other LAMPIRE products and services related to the pandemic investigation. […]

August 7, 2020

Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies.

An emerging body of evidence has been involved in plasminogen activator inhibitor-1 (PAI-1) in the development of type 2 diabetes (T2D), though the findings are not always consistent. Our systematic epidemiological studies examining the association of PAI-1 with T2D. EMBASE, PubMed, Web of Science, and the Cochrane Library were searched to identify studies for inclusion. Fifty-two studies (44 cross-sectional with 47 unique analytical comparisons and […]

August 7, 2020

Deficiency of plasminogen activator inhibitor 2 in plasma of patients with hereditary angioedema with normal C1 inhibitor levels.

Hereditary angioedema with normal levels of C1 inhibitor (HAE-N) is associated with mutations in Factor XII in 30% of subjects; However, the role of this mutation in the pathogenesis of angioedema is unclear.We are looking for evidence of abnormalities in the pathway of bradykinin bradykinin formation and degradation in the plasma of patients with HAE-N both with and without the mutation. Bradykinin has been added […]

August 7, 2020

Deficiency of Plasminogen Activator Inhibitor Type 2 Limits Brain Edema Formation after Traumatic Brain Injury.

Plasminogen activator inhibitor-2 (PAI-2 / SerpinB2) inhibits extracellular urokinase plasminogen activator (uPA). In physiological conditions, PAI-2 is expressed at low levels but quickly due to triggers inflammation. This is a negative regulator of fibrinolysis and serves to stabilize the clot. In this study, PAI-2 expression upregulated 25 fold in the brain tissues pericontusional at 6 hours after traumatic brain injury (TBI), with a maximum increase […]

August 7, 2020

Elevated Expression of Vascular Adhesion Molecule-1, Plasminogen Activator Inhibitor-1, Cyclooxygenase-2, and Thrombomodulin in Human Umbilical Vein Endothelial Cells from Hospitalized Gestational Diabetes Mellitus Patients.

protein expression in human umbilical vein endothelial cells (HUVECs) is a useful indicator of the condition of the mother during pregnancy and the intrauterine environment. Therefore, we examined the protein expression in HUVECs were obtained from patients with gestational diabetes mellitus (GDM). HUVECs were made from the umbilical cord and control GDM patients undergoing planned caesarean section between 2013 and 2014 at Teikyo University Hospital […]