Deficiency of Plasminogen Activator Inhibitor Type 2 Limits Brain Edema Formation after Traumatic Brain Injury.
Plasminogen activator inhibitor-2 (PAI-2 / SerpinB2) inhibits extracellular urokinase plasminogen activator (uPA). In physiological conditions, PAI-2 is expressed at low levels but quickly due to triggers inflammation. This is a negative regulator of fibrinolysis and serves to stabilize the clot. In this study, PAI-2 expression upregulated 25 fold in the brain tissues pericontusional at 6 hours after traumatic brain injury (TBI), with a maximum increase […]