August 7, 2020
Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin.
Rho-kinase (ROCK) inhibition, widely used in cardiovascular disease, could protect the blood-brain barrier (BBB) from damage during thrombolysis rt-PA-induced. While the use of inhibitors of ROCK nonselective as fasudil together with rt-PA can be deterred by the possibility of hypotension side effects and inadequate capacity to block the activity of rt-PA detrimental to endothelial cells of the brain (BEC), a selective ROCK-2 inhibition may overcome […]